'Chaperone' compounds offer new approach to Alzheimer's treatment

A wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex has been devised by researchers. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer's.